26 back-roads routes start within a 4.5-hour drive of Knoxville, including 3 day trips and 19 weekend drives; 1 ready-made itinerary begins nearby.
Drive times are estimates to the nearer end of each route (straight-line miles plus a quarter, at 50 mph); the atlas itself never routes you onto an interstate once the drive begins.
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The nearest way in is US 11E: The Great Valley Road (Knoxville → Bristol) — starts in Knoxville; ~110 miles over 1–2 days.
US 11E: The Great Valley Road (Knoxville → Bristol) — starts in Knoxville; ~110 miles over 1–2 days — short enough to drive out and back, or stay a night.
The Dragon & the Skyway (Loop from Gatlinburg) — about 45 min to Loop from Gatlinburg; ~280 miles over 2–3 days.
Blue Ridge Parkway & the Smokies begins about 1 h 10 min away at Cherokee (+ Smokies spurs).