9 back-roads routes start within a 4.5-hour drive of Myrtle Beach, including 0 day trips and 7 weekend drives; 0 ready-made itineraries begin nearby.
Drive times are estimates to the nearer end of each route (straight-line miles plus a quarter, at 50 mph); the atlas itself never routes you onto an interstate once the drive begins.
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The nearest way in is Kings Highway & the Lowcountry (Wilmington → Savannah) — about 1 h 40 min to Wilmington; ~290 miles over 3–4 days.
No one-day route starts within 2.5 hours of Myrtle Beach; the nearest route overall is Kings Highway & the Lowcountry (Wilmington → Savannah) — about 1 h 40 min to Wilmington; ~290 miles over 3–4 days.
US 301: The Ghost Road (Emporia → Santee) — about 2 h 20 min to Santee; ~290 miles over 2–3 days.
US 64: The Waterfall Byway begins about 6 h 5 min away at Brevard, beyond the 4.5-hour reach of a weekend start.