Ozarks, Ouachitas & the Bootheel

States: Tennessee · Arkansas · Missouri

Start near: Memphis (starts here)

The Bootheel: US 61 North

earthquake country and throwed rolls

The Bootheel: US 61 North is a ~175-mile back-roads route from Memphis to Cape Girardeau on US 61, driven in 1–2 days, that stays off I-55 through the Ozarks, Ouachitas & the Bootheel.

Open the interactive map →

Drive
Memphis → Cape Girardeau
Distance
~175 miles
Time
1–2 days
Highways
US 61
Avoids
I-55
Region
Ozarks, Ouachitas & the Bootheel

The Blues Highway runs both directions out of Memphis. North, US 61 crosses the Arkansas line into Missouri's Bootheel, where the 1811-12 New Madrid earthquakes, the strongest ever recorded east of the Rockies, made the Mississippi run backward and rang church bells on the Atlantic seaboard, or so the newspapers swore. Add a jewel-box deco bus station, rolls thrown at your head in Sikeston, and a floodwall painted with the river's whole story.

📍 New Madrid's museum and river deck carry the quake story; Trail of Tears State Park marks the winter crossings.

The drive, segment by segment

The Arkansas Prelude

Memphis → Blytheville · ~65 mi

Cotton flats and blues ghosts north through Osceola to Blytheville's deco Greyhound gem.

Quake Country

Blytheville → New Madrid · ~55 mi

Caruthersville's river landing and the seismic capital of the Midwest, where the observation deck watches the bend that once flowed the wrong way.

Rolls & the River

New Madrid → Cape Girardeau · ~55 mi

Sikeston's flying-carbohydrate institution, then the Cherokee crossing at Trail of Tears and Cape's painted floodwall.

Tips and best time to go

Frequently asked questions

How long is The Bootheel: US 61 North and how many days does it take?

The Bootheel: US 61 North is about 175 miles and takes 1–2 days at a back-roads pace.

Where does The Bootheel: US 61 North start and end?

It runs from Memphis to Cape Girardeau.

Which highways does The Bootheel: US 61 North follow?

It follows US 61.

Which interstate does The Bootheel: US 61 North replace?

It avoids I-55, using US 61 instead.

How many stops are on The Bootheel: US 61 North, and what are the highlights?

6 stops are mapped, including Blytheville Greyhound Station, New Madrid Museum & River Deck, Hunter-Dawson Home, Lambert's Café and Trail of Tears State Park.

Worth a detour

More back-roads routes

Connects with: US 70: Broadway of America · The Blues Highway · The Hill Country Ramble

More in the Ozarks, Ouachitas & the Bootheel: Arkansas 7: The Scenic Seven · Crowley's Ridge Parkway · The Arkansas Delta · Talimena & the Ouachitas · The Pig Trail & Eureka · The Buffalo River Loop

Browse all 91 routes → · Ready-made itineraries →