3 back-roads routes touch West Virginia, with 18 curated stops along them and 1 ready-made itinerary crossing the state.
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3 routes cross West Virginia, from 1 day to 2 days each; driven back to back they add up to about 380 miles.
The Quiet Zone at about 160 miles (Lewisburg → Petersburg, WV), a 2-day drive.
US 52: The Mine Wars Road: about 100 miles, 1–2 days, Bluefield → Williamson.
All 3 of these routes stay inside West Virginia.